Abstract According to statistics, by 2020 the world will be 80 million glaucoma patients; Glaucoma An eye homeostasis by the housing cycle of destruction caused by increased intraocular pressure, causing the optic disc depression, visual field defects, can eventually lead to blindness Serious eye disease. For the treatment of glaucoma...
According to statistics, there will be 80 million glaucoma patients worldwide by 2020; glaucoma, an increase in intraocular pressure caused by the destruction of the dynamic balance of the aqueous humor in the eye, causing disc depression and visual field defects, which can eventually lead to serious blindness. Eye disease. For the treatment of glaucoma, foreign technology now generally uses eye drops for adjuvant treatment, protecting eyelids and reducing excessive release of aqueous humor. In the actual treatment, some patients insisted that the medication formula and the treatment process were not in place, leading to side effects. Recently, the Department of Dental Research at the University of California, Los Angeles (UCLA) has developed a drug delivery technology for the treatment of glaucoma with few side effects. The scientists carried the therapeutic drug on the artificial nano-diamond and embedded it on the contact lens; when the patient wears the contact lens, the drug enters the affected part with the tear, thereby achieving the therapeutic effect. As a lasting treatment, this technique works well in clinical trials; another added benefit is that with the addition of nanodiamonds, the durability of contact lenses is greatly increased, reducing the number of lens replacements.
In order to provide stable drug delivery and treatment to the eye, the researchers applied the therapeutic drug timolol maleate to the nanodiamond and then embedded the diamond into the contact lens. When timolol maleate enters the eye, it combines with a substance called lysozyme in tears to achieve therapeutic effects.
The traditional timolol maleate treatment is carried out by means of eye drops, but the effective dose to actually reach the affected part of the eye is only 5%; another defect is excessive use, when a large drop of eye After the drug drops into the eye, the excessive dose causes an irregular heartbeat, while wasting the practical application of the effective drug.
The staff found that the optical properties of the contact lens were not affected after the embedded nano-diamond; although the texture was stronger than the ordinary lens, the moisture content of the lens film did not change significantly, which means the comfort of the lens and Oxygen permeability was also unaffected.
Dr. No-Hee Park, Director of the Department of Dentistry, commented that Professor Dean Ho is a scientific visionary in his field of research. The breakthrough in nano-diamond technology in glaucoma treatment once again witnessed the power of science and refreshed the Dean Ho team. Efforts to journey.
The research was sponsored by Northwestern University and the Korean University of Korea. (Compiled from 'Nanodiamond-embedded contact lenses may improve glaucoma treatment')
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