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According to the report of the Physicist Organization Network on May 30th, researchers from the University of California at Santa Barbara and the Scripps Research Institute have jointly developed artificial platelets, and relevant research reports are published in the recently published "Advanced Materials." Magazine.
Platelets are large numbers of non-nucleated discoid cells present in the blood and can play an important role in hemostasis, wound healing, inflammatory response, and thrombosis. In addition, platelets have a specific morphological and biochemical composition, ranging in diameter from 2 μm to 4 μm, much smaller than red blood cells, and have a more stable amount in normal blood.
Researchers say that artificial blood platelets can be applied to many biomedical fields before further optimization and thorough testing. The challenge they face is to develop an equal-sized particle that gives it the key structural characteristics that natural platelets possess.
In order to simulate the size, shape and surface function of natural platelets, polymer particles can be a very suitable alternative. However, polymer particles are much harder than platelets. To solve this problem, the researchers used a polymer "template."
This core is located on a multi-layered protein and polyelectrolyte and can create stable artificial platelet-like particles by deposition, layering, and cross-linking. Subsequently, the hard polymer core will dissolve and give the particles the required elasticity or flexibility, and the particles will also be smeared with proteins found on the surface of activated natural platelets or damaged blood vessels.
Scientists say that such artificial platelets may not only perform typical natural platelet functions, but may also be used to carry imaging agents to confirm damaged blood vessels or to deliver drugs to achieve thrombolysis. They stated that this progress is a milestone for the development of biomimetic materials and a good example of material synthesis used to solve medical problems. By using its expertise in platelet biology, artificial blood platelets can be combined with unique physical and Biological properties mimic natural platelets, which have a profound effect on trauma caused by warfare and surgery. Earlier, researchers at Santa Barbara had also successfully synthesized red blood cells. (Reporter: Zhang Hao)
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